{"id":6659,"date":"2024-04-09T13:30:59","date_gmt":"2024-04-09T13:30:59","guid":{"rendered":"https:\/\/www.solidpharma.be\/?p=6659"},"modified":"2024-04-09T13:55:30","modified_gmt":"2024-04-09T13:55:30","slug":"ingredient-onder-de-loep-gaba-gamma-aminoboterzuur","status":"publish","type":"post","link":"https:\/\/www.solidpharma.be\/nl\/ingredient-onder-de-loep-gaba-gamma-aminoboterzuur\/","title":{"rendered":"Ingredi\u00ebnt onder de loep: GABA (gamma-aminoboterzuur)"},"content":{"rendered":"[vc_row type=&#8221;in_container&#8221; full_screen_row_position=&#8221;middle&#8221; column_margin=&#8221;default&#8221; column_direction=&#8221;default&#8221; column_direction_tablet=&#8221;default&#8221; column_direction_phone=&#8221;default&#8221; scene_position=&#8221;center&#8221; text_color=&#8221;dark&#8221; text_align=&#8221;left&#8221; row_border_radius=&#8221;none&#8221; row_border_radius_applies=&#8221;bg&#8221; overflow=&#8221;visible&#8221; overlay_strength=&#8221;0.3&#8243; gradient_direction=&#8221;left_to_right&#8221; shape_divider_position=&#8221;bottom&#8221; bg_image_animation=&#8221;none&#8221;][vc_column column_padding=&#8221;no-extra-padding&#8221; column_padding_tablet=&#8221;inherit&#8221; column_padding_phone=&#8221;inherit&#8221; column_padding_position=&#8221;all&#8221; column_element_direction_desktop=&#8221;default&#8221; column_element_spacing=&#8221;default&#8221; desktop_text_alignment=&#8221;default&#8221; tablet_text_alignment=&#8221;default&#8221; phone_text_alignment=&#8221;default&#8221; background_color_opacity=&#8221;1&#8243; background_hover_color_opacity=&#8221;1&#8243; column_backdrop_filter=&#8221;none&#8221; column_shadow=&#8221;none&#8221; column_border_radius=&#8221;none&#8221; column_link_target=&#8221;_self&#8221; column_position=&#8221;default&#8221; gradient_direction=&#8221;left_to_right&#8221; overlay_strength=&#8221;0.3&#8243; width=&#8221;1\/1&#8243; tablet_width_inherit=&#8221;default&#8221; animation_type=&#8221;default&#8221; bg_image_animation=&#8221;none&#8221; border_type=&#8221;simple&#8221; column_border_width=&#8221;none&#8221; column_border_style=&#8221;solid&#8221;][vc_column_text text_direction=&#8221;default&#8221;]\n<h4>Glutamine, glutaminezuur en GABA (gamma-aminoboterzuur) zijn drie aan elkaar verwante niet-essenti\u00eble aminozuren die een belangrijke functie spelen in de hersenen en het doorgeven van signalen tussen zenuwcellen. Glutaminezuur (glutamaat) kan omgezet worden in glutamine en GABA. Een belangrijke cofactor in de omzetting naar GABA is vitamine B6 en taurine.<br \/>\nGlutaminezuur is een stimulerende neurotransmitter: het activeert de overdracht van zenuwprikkels (exciterend effect).<\/h4>\n<h4>GABA is een kalmerende neurotransmitter: het remt de overdracht van zenuwprikkels (kalmerend effect), voorkomt overactieve hersenen en bevordert ontspanning.<br \/>\nGlutamine is een energiebron voor hersenen en reguleert de activiteit van glutaminezuur en GABA.<\/h4>\n[\/vc_column_text][\/vc_column][\/vc_row][vc_row type=&#8221;in_container&#8221; full_screen_row_position=&#8221;middle&#8221; column_margin=&#8221;default&#8221; column_direction=&#8221;default&#8221; column_direction_tablet=&#8221;default&#8221; column_direction_phone=&#8221;default&#8221; scene_position=&#8221;center&#8221; text_color=&#8221;dark&#8221; text_align=&#8221;left&#8221; row_border_radius=&#8221;none&#8221; row_border_radius_applies=&#8221;bg&#8221; overflow=&#8221;visible&#8221; overlay_strength=&#8221;0.3&#8243; gradient_direction=&#8221;left_to_right&#8221; shape_divider_position=&#8221;bottom&#8221; bg_image_animation=&#8221;none&#8221;][vc_column column_padding=&#8221;no-extra-padding&#8221; column_padding_tablet=&#8221;inherit&#8221; column_padding_phone=&#8221;inherit&#8221; column_padding_position=&#8221;all&#8221; column_element_direction_desktop=&#8221;default&#8221; column_element_spacing=&#8221;default&#8221; desktop_text_alignment=&#8221;default&#8221; tablet_text_alignment=&#8221;default&#8221; phone_text_alignment=&#8221;default&#8221; background_color_opacity=&#8221;1&#8243; background_hover_color_opacity=&#8221;1&#8243; column_backdrop_filter=&#8221;none&#8221; column_shadow=&#8221;none&#8221; column_border_radius=&#8221;none&#8221; column_link_target=&#8221;_self&#8221; column_position=&#8221;default&#8221; gradient_direction=&#8221;left_to_right&#8221; overlay_strength=&#8221;0.3&#8243; width=&#8221;1\/1&#8243; tablet_width_inherit=&#8221;default&#8221; animation_type=&#8221;default&#8221; bg_image_animation=&#8221;none&#8221; border_type=&#8221;simple&#8221; column_border_width=&#8221;none&#8221; column_border_style=&#8221;solid&#8221;][vc_column_text text_direction=&#8221;default&#8221;]<strong>Bronnen<\/strong><\/p>\n<ul>\n<li>endogene productie uit glutaminezuur door decarboxylatie met behulp van het actieve vitamine B6 en magnesium als cofactoren (synthese gestimuleerd door intensieve bewegingen )<\/li>\n<li>voeding: tuinbonen, groene bladgroenten, tomaten, sojabonen, noten en zaden.<\/li>\n<li>productie door darmmicrobioom<\/li>\n<\/ul>\n<p><strong>Dosering<\/strong><\/p>\n<ul>\n<li>Voor slaap \u2013 en angststoornissen worden routinematig dosissen van 100-800mg gebruikt, eventueel verdeeld over verschillende innamemomenten.<\/li>\n<\/ul>\n<p><strong>Werkingsmechanisme<\/strong><\/p>\n<ul>\n<li>kalmerende inhiberende neurotransmitter: GABA A receptor zorgt voor een balans tussen activiteit en rust. GABA B receptor be\u00ebindigt de overactiviteit van de hersenen. (GABA remt de stimulerende werking van glutamaat)<\/li>\n<li>anti-oxidant<\/li>\n<li>stimuleert aanmaak van prolactine<\/li>\n<li>natuurlijke spierontspanner<\/li>\n<\/ul>\n<p>GABA kan hersen-bloedbarri\u00e8re moeilijk passeren, maar toch wordt GABA vaak ingezet met positieve resultaten. Een verklaring zou kunnen zijn dat GABA perifeer aanwezig wel een positief effect kent op GABA in het centraal zenuwstelsel (via de darm-hersenas).<\/p>\n<p><strong>Veiligheid<\/strong><\/p>\n<ul>\n<li>GABA wordt goed getolereerd en dit werd uitvoerig bestudeerd in verschillende studies. Hoge dosissen veroorzaken misselijkheid, kortademigheid, angst, flush, lage bloeddruk en tintelingen in de handen.<\/li>\n<li>Er zijn onvoldoende onderzoeken bij zwangere vrouwen en vrouwen die borstvoeding geven.<\/li>\n<li>Let op voor interactie met bloeddrukverlagende medicatie.<\/li>\n<\/ul>\n<p><strong>In de praktijk inzetbaar bij<br \/>\n<\/strong><\/p>\n<ul>\n<li>Stress en stress gerelateerde symptomen zoals hyperactiviteit, angst, hoofdpijn en irritatie.<\/li>\n<li>Slapeloosheid<\/li>\n<\/ul>\n[\/vc_column_text][\/vc_column][\/vc_row][vc_row type=&#8221;in_container&#8221; full_screen_row_position=&#8221;middle&#8221; column_margin=&#8221;default&#8221; column_direction=&#8221;default&#8221; column_direction_tablet=&#8221;default&#8221; column_direction_phone=&#8221;default&#8221; scene_position=&#8221;center&#8221; text_color=&#8221;dark&#8221; text_align=&#8221;left&#8221; row_border_radius=&#8221;none&#8221; row_border_radius_applies=&#8221;bg&#8221; overflow=&#8221;visible&#8221; overlay_strength=&#8221;0.3&#8243; gradient_direction=&#8221;left_to_right&#8221; shape_divider_position=&#8221;bottom&#8221; bg_image_animation=&#8221;none&#8221;][vc_column column_padding=&#8221;no-extra-padding&#8221; column_padding_tablet=&#8221;inherit&#8221; column_padding_phone=&#8221;inherit&#8221; column_padding_position=&#8221;all&#8221; column_element_direction_desktop=&#8221;default&#8221; column_element_spacing=&#8221;default&#8221; desktop_text_alignment=&#8221;default&#8221; tablet_text_alignment=&#8221;default&#8221; phone_text_alignment=&#8221;default&#8221; background_color_opacity=&#8221;1&#8243; background_hover_color_opacity=&#8221;1&#8243; column_backdrop_filter=&#8221;none&#8221; column_shadow=&#8221;none&#8221; column_border_radius=&#8221;none&#8221; column_link_target=&#8221;_self&#8221; column_position=&#8221;default&#8221; gradient_direction=&#8221;left_to_right&#8221; overlay_strength=&#8221;0.3&#8243; width=&#8221;1\/1&#8243; tablet_width_inherit=&#8221;default&#8221; animation_type=&#8221;default&#8221; bg_image_animation=&#8221;none&#8221; border_type=&#8221;simple&#8221; column_border_width=&#8221;none&#8221; column_border_style=&#8221;solid&#8221;][image_with_animation image_url=&#8221;6674&#8243; image_size=&#8221;full&#8221; animation_type=&#8221;entrance&#8221; animation=&#8221;None&#8221; animation_movement_type=&#8221;transform_y&#8221; hover_animation=&#8221;none&#8221; alignment=&#8221;&#8221; border_radius=&#8221;none&#8221; box_shadow=&#8221;none&#8221; image_loading=&#8221;default&#8221; max_width=&#8221;100%&#8221; max_width_mobile=&#8221;default&#8221;][\/vc_column][\/vc_row]\n","protected":false},"excerpt":{"rendered":"<p>[vc_row type=&#8221;in_container&#8221; full_screen_row_position=&#8221;middle&#8221; column_margin=&#8221;default&#8221; column_direction=&#8221;default&#8221; column_direction_tablet=&#8221;default&#8221; column_direction_phone=&#8221;default&#8221; scene_position=&#8221;center&#8221; text_color=&#8221;dark&#8221; 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